Field Instrument 006

Your two o'clock coffee is still awake at midnight.

Caffeine has a half-life of about five hours, which means half of it is still in you five hours later, and a quarter of it ten hours later. Most people who sleep badly and have "cut back on caffeine" are still drinking it far too late. Here is the arithmetic, drawn.

Scientific Receipt, Caffeine follows first-order elimination with a mean half-life near five hours in healthy adults, though the range across individuals is roughly 1.5 to 9.5 hours depending on CYP1A2 activity, oral contraceptive use, pregnancy and smoking (Institute of Medicine, Caffeine for the Sustainment of Mental Task Performance, 2001). In a controlled trial, 400mg taken six hours before bed reduced total sleep time by more than an hour, and participants did not reliably detect the disruption themselves (Drake et al., Journal of Clinical Sleep Medicine, 2013). Read the full evidence review →